Quick Navigation

Overview Topics Abstract Importance Paper Tools References Reactions Discussion Publication Related

Topics

Quantum State Preparation Representation Quantum Simulation Quantum Machine Learning Quantum Chemistry

Total Synthesis of (±)- and (+)-Euphohyrisnoid A.

PubMed

Authors: Ye ZH, Ao QQ, Peng YC, Liu X, Lin X, Li CC

Year

2026

Paper ID

9743

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

Citations

Abstract

The first total synthesis of (±)- and (+)-euphohyrisnoid A, a highly rearranged lathyrane diterpenoid with a new [5-7-6-6] tetracyclic core, was accomplished. The synthesis was strategically guided by a mild intramolecular Diels-Alder (IMDA) reaction, which efficiently constructed the pivotal bicyclo[2.2.2] ring system with high diastereoselectivity. This outcome experimentally validated prior quantum mechanical calculations. The IMDA precursor was assembled efficiently via a Tsuji-Trost reaction. The desired seven stereocenters, including two quaternary stereocenters in the final product, were constructed diastereoselectively.

Why This Paper Matters

This paper contributes to the Quantum Machine Learning research area in the Quantum Articles archive.
It adds a 2026 reference point for readers tracking recent quantum research.
The first total synthesis of (±)- and (+)-euphohyrisnoid A, a highly rearranged lathyrane diterpenoid with a new [5-7-6-6] tetracyclic core, was accomplished.

Paper Tools

Become a member to use research tools

Sign in to open papers, visit source links, share, cite, compare, copy DOI links, request category corrections, and build your reading list.

Become a member Sign in

Publisher Share Cite This Paper Copy URL Compare Copy DOI Add to Reading List Category Correction Request

References & Citation Signals

[1] DOI https://doi.org/10.1021/jacs.6c00187 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/41649279/

Local Citation Graph (Related-Paper Links)

External citation index: OpenAlex citation signal • updated 2026-10-22 12:25:36

Community Reactions

Quick sentiment from readers on this paper.

Score: 0

Likes: 0 Dislikes: 0

Discussion & Reviews (Moderated)

Average Rating: 0.0 / 5 (0 ratings)

No written reviews yet.