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Minor Lignans with Inhibitory Activity against LPS-Induced NO Production from Schisandra Chinensis.

PubMed
Authors: Sun P, Zhuang XC, Ao R, Zhang H

Year

2025

Paper ID

9572

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

91

Citations

1

Abstract

Phytochemical investigation into the fruits of Schisandra chinensis led to the isolation of seven new minor lignans, schisanchignans A-G (1-7), including one benzofuran type (1), three aryltetralin type (2-4) and three tetrahydrofuran type (5-7). Their structures were established by comprehensive spectroscopic analyses, and the absolute configurations were determined by electronic circular dichroism technique including quantum chemical calculation method. Of note, this is the first report of nor-benzofuran and aryltetralin types of lignans from S. chinensis. Compounds 1, 3 and 4 exhibited mild inhibitory activity against the lipopolysaccharide-induced production of nitric oxide in murine RAW264.7 cells.

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  • Phytochemical investigation into the fruits of Schisandra chinensis led to the isolation of seven new minor lignans, schisanchignans A-G (1-7), including one benzofuran type...

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References & Citation Signals

[1] DOI https://doi.org/10.1002/cbdv.202402354 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/39500739/

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