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Quantum State Preparation Representation Quantum Chemistry

Anti-Inflammatory Secoiridoids from the Medicinal Herb Gentianopsis barbata.

PubMed
Authors: Liu H, Cheng HZ, Qi XY, Fan YZ, Yuan ZZ, Xu YL, Liu Y, Guo K, Li SH

Year

2025

Paper ID

9571

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

93

Citations

0

Abstract

Five new secoiridoids, gentianopsins A-E (1-5), along with two known analogues (6 and 7) were isolated from the whole plants of the medicinal herb Gentianopsis barbata. Their structures were elucidated by a comparison of extensive spectroscopic analysis (1D and 2D NMR, and HRMS) and quantum chemical calculations. Gentianopsins A (1) and B (2) represented two unusual skeletons of trihomo-secoiridoids. Anti-inflammatory activity of these isolates was evaluated via suppressing the secretion of cytokines TNF-α and IL-6 in LPS-induced macrophages RAW264.7. Significant inhibitory activity was observed for compounds 3 and 7 on IL-6 secretion with IC values of 10.22 and 13.30 μM, respectively.

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  • This paper contributes to the Quantum Chemistry research area in the Quantum Articles archive.
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  • Five new secoiridoids, gentianopsins A-E (1-5), along with two known analogues (6 and 7) were isolated from the whole plants of the medicinal herb Gentianopsis barbata.

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References & Citation Signals

[1] DOI https://doi.org/10.1002/cbdv.202402653 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/39528401/

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