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Discovery of metabolites from the (Periplaneta americana)-derived endophytic Nigrospora oryzae SMU02 and their anti-inflammatory activity.

PubMed
Authors: Wu LY, He HZ, Xue JH, Qiu XH, Cheng X, Luo Q, Chen YP

Year

2026

Paper ID

38514

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

97

Citations

0

Abstract

Insect endophytic fungi represent a rich source of structurally diverse and biologically active compounds. From the endophytic fungus SMU02, isolated from the insect , five metabolites were obtained, including a novel citrinin trimer, neotricitrinol D () and four known dimers -. Neotricitrinol D () features a novel carbon skeleton with a 6/6/5/5/6/6/6/6 octacyclic system, one of the few such structures reported to date. The chemical structure was determined based on spectral data and quantum chemical calculation. Additionally, the anti-inflammatory properties of the isolates - were also evaluated, compound exhibited a significant inhibitory effect on NO production with IC value of 3.93 μM.

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  • This paper contributes to the Quantum Chemistry research area in the Quantum Articles archive.
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  • Insect endophytic fungi represent a rich source of structurally diverse and biologically active compounds.

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References & Citation Signals

[1] DOI https://doi.org/10.1080/14786419.2026.2645749 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/41854108/

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External citation index: OpenAlex citation signal • updated 2026-06-14 04:29:14

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