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Quantum Chemistry

Deuterium and its role in the machinery of evolution.

PubMed

Authors: Pedersen LG, Bartolotti L, Li L

Year

2006

Paper ID

12807

Status

Peer-reviewed

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~2 min

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Abstract

An argument is presented that the spontaneous mutation rate, the core of evolution theory, may be dictated by the deuterium/hydrogen (D/H) abundance ratio. This argument is supported by quantum mechanical calculations of the zero-point energy reduction for DNA base pairs upon deuterium substitution for hydrogen and recent experiments that show that the rate of catalytic dsDNA unwinding is dependent on the stability of the dsDNA.

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An argument is presented that the spontaneous mutation rate, the core of evolution theory, may be dictated by the deuterium/hydrogen (D/H) abundance ratio.

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References & Citation Signals

[1] DOI https://doi.org/10.1016/j.jtbi.2005.07.002 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/16098990/

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