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Characterization of the PEG layer of sterically stabilized liposomes: a SAXS study.

PubMed
Authors: Varga Z, Wacha A, Vainio U, Gummel J, Bóta A

Year

2012

Paper ID

12223

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

94

Citations

N/A

Abstract

Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG) layers to the total electron density was identified. The changes in the thickness of the PEG layer as well as the distribution of the PEG chains among the outer and inner leaflets of the bilayers were followed by changing the molar ratio of the PEG-lipid and the molar weight of the PEG molecule.

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  • This paper contributes to the Quantum Chemistry research area in the Quantum Articles archive.
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  • Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented.

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References & Citation Signals

[1] DOI https://doi.org/10.1016/j.chemphyslip.2011.12.011 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/22227108/

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