A new cytochalasan metabolite with cytotoxic activity from the mangrove endophytic fungus Talaromyces sp. GDUT-10.

An undescribed cytochalasan talarochalasin (), with four known analogues 20-deoxycytochalasin F (), cytochalasin F (), cytochalasin B (), and cytochalasin T () were obtained from the mangrove endophytic fungus sp. GDUT-10. Their structures were determined through the comprehensive analysis of NMR, HR-ESIMS spectra, quantum chemical ECD calculations, and quantum chemical calculation of C NMR combined with DP4 probability analysis. The compounds were evaluated for their cytotoxic and α-glucosidase inhibitory activities. Compounds showed cytotoxic activities against three cancer cell lines, including VCaP, PC-3, and T-24, with IC values ranging from 10.35 ± 0.23 μmol/L to 38.15 ± 0.90 μmol/L. Compound showed weak cytotoxic activities against VCaP and T-24 cell lines. While these cytochalasans showed no inhibition against α-glucosidase.