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Target isolation of diverse sesquiterpenoid from the stems of Daphne genkwa based on molecular networking.
PubMed
Authors: Li JY, Wang XY, Han MJ, Bai M, Huang XX
Year
2025
Paper ID
850
Status
Peer-reviewed
Abstract Read
~2 min
Abstract Words
81
Citations
N/A
Abstract
Guiding by LC-MS/MS analysis and the Global Natural Products Social (GNPS) Molecular Networking, three undescribed sesquiterpenoids, stedapgens A-C, and two known analogues were discovered in the barks of Sieb. et Zucc. The structures were determined by analysis of their spectroscopic data and quantum-chemical calculations. All the isolated novel compounds were tested for their acetylcholinesterase inhibitory activities with IC = 0.754 ± 0.059, 0.696 ± 0.026, and 0.337 ± 0.023 g/ml. Among them, stedapgen A displayed promising inhibitory activities against AChE, and the binding sites were predicted by molecular docking.
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- Guiding by LC-MS/MS analysis and the Global Natural Products Social (GNPS) Molecular Networking, three undescribed sesquiterpenoids, stedapgens A-C, and two known analogues...
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