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Inhibition of Mincle signaling by chemically synthesized disaccharide-type 6-O-acylated steryl β-glucosides (βASGs) and their analogues derived from plants.

PubMed
Authors: Yoshida K, Matsumaru T, Yamasaki S, Fujimoto Y

Year

2026

Paper ID

72077

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

42

Citations

N/A

Abstract

Chemically synthesized disaccharide βASGs from and analogues effectively block Mincle-mediated signaling. This Mincle signaling inhibition requires a disaccharide backbone with sterol and fatty acid moieties, suggesting these glycolipids as key structural templates for developing novel anti-inflammatory therapeutics targeting this C-type lectin receptor.

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  • Chemically synthesized disaccharide βASGs from and analogues effectively block Mincle-mediated signaling.

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