Chirality-induced stereoselective synthesis of chiral sp(2)-carbon-conjugated covalent organic frameworks.

A fully conjugated sp-carbon covalent organic framework (spC-COF) possessing global conformational chirality holds great promise for advanced electronic devices. However, the inherent irreversibility of many reactions hinders the chirality-induced synthesis of COFs from achiral building blocks. Herein, we address a chirality-induced linkage exchange strategy to fabricate a vinylene-linked chiral spC-COF an irreversible aldol reaction. The approach involves the pre-synthesis of a chiral Schiff-base precursor, followed by its acid-catalyzed conversion from imine to vinylene linkages. This chiral precursor induces the orientation of asymmetric vinylene linkages, enabling the enantioselective formation of periodic frameworks. Through a self-template mechanism, the layered stacking amplifies the structural chirality and dominates the evolution of branched nanofibers. The resulting chiral spC-COF exhibits a high dissymmetry factor in circularly polarized luminescence along with a substantial quantum yield, achieving a superior figure of merit of up to 0.01. An ultrathin film of the chiral spC-COF is fabricated and implemented in an interdigitated capacitive sensor capable of the simultaneous quantification and chiral recognition of tryptophan within the 10-40 µM range. This work not only provides a strategic pathway to overcome chiral propagation barriers in irreversible reactions but also introduces an emerging class of chiral two-dimensional carbon materials.