La Testosterona Como Modulador Redox Directo: Evidencia Cuántica in Silico de sus Acciones Oxidantes y Antioxidantes Sobre los Aminoácidos Humanos

Testosterone (TTT) has been extensively studied as a steroid hormone, yet its role as a direct redox modulator remains unexplored. This work presents computational evidence demonstrating its capacity to act as both an oxidizing and a reducing agent toward amino acids (AAs) and protein‑like systems. Using electronic structure calculations, quantum‑well analysis, and statistical ordering of molecular interactions, we identify consistent patterns of electron transfer that depend on the chemical context. The results show that TTT can either compact or expand the electronic cloud of biomolecules depending on the interaction type, thereby modulating their intrinsic reactivity. The observed oxidant/antioxidant duality suggests a broader role for TTT in redox biology, with potential implications for neuroscience, aging, reproduction, and steroid pharmacology. This study proposes a new conceptual framework in which testosterone operates as a direct redox modulator, influencing the electronic stability of complex biomolecular systems.