Exponential Quantum Speedup on Structured Hard Instances of Maximum Independent Set

Establishing quantum speedup for computationally hard problems of practical relevance, particularly combinatorial optimization problems, remains a central challenge in quantum computation. In this work, we identify a structurally defined family of classically hard maximum independent set (MIS) instances, and design and analyze a non-stoquastic adiabatic quantum optimization algorithm that exploits this structure. The algorithm runs in polynomial time and achieves an exponential speedup over both transverse-field quantum annealing and state-of-the-art classical solvers on these instances, under assumptions supported by analytical and numerical evidence. We identify the essential quantum mechanism enabling the speedup as the use of a non-stoquastic XX-driver to access a larger sign-structured admissible subspace beyond the stoquastic regime, which allows sign-generating quantum interference to create smooth evolution paths that bypass tunneling. This identifies a distinctive quantum mechanism underlying the speedup and explains why no efficient classical analogue is likely to exist. In addition, our analysis produces scalable small-scale models, derived from our structural reduction, that capture the essential dynamics of the algorithm. These models provide a concrete opportunity for verification of the quantum advantage mechanism on currently available universal quantum computers.