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Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy

DOAJ
Authors: Le Xu, Tiantian Zhang, Bingcheng Huang, Fangmei Zheng, Yan Huang, Yuyang Li, Yiru Peng, Linying Chen

Year

2023

Paper ID

30493

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

95

Citations

4

Abstract

The development of efficient photosensitizers with high singlet oxygen quantum yield, strong fluorescent emission, excellent photostability, and specific organelle targeting is in great demand for the enhancement of PDT treatment efficiency. This study designed and synthesized a new two-photon photosensitizer chlorophenyl thiophene axially substituted silicon (IV) phthalocyanine (CBT-SiPc). CBT-SiPc showed specific targeting of lysosomes in living cells and good biocompatibility. Furthermore, high 1O2 generation efficiency and high PDT efficiency in MCF-7 breast cancers under irradiation were also demonstrated. The novel CBT-SiPc showed great potential in the application of lysosome-targeted and two-photon bioimaging-guided photodynamic cancer therapy.

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  • The development of efficient photosensitizers with high singlet oxygen quantum yield, strong fluorescent emission, excellent photostability, and specific organelle targeting is...

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References & Citation Signals

[1] DOI https://doi.org/10.3389/fphar.2023.1168393 [2] Publisher https://www.frontiersin.org/articles/10.3389/fphar.2023.1168393/full

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External citation index: OpenAlex citation signal • updated 2026-10-21 11:45:01

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