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Quantum State Preparation Representation

Bio-orthogonal AIE Dots Based on Polyyne-Bridged Red-emissive AIEgen for Tumor Metabolic Labeling and Targeted Imaging.

PubMed
Authors: Zhang P, Jiang T, Li Y, Zhao Z, Gong P, Cai L, Kwok RTK, Lam JWY, Gu X, Tang BZ

Year

2019

Paper ID

1662

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

102

Citations

14

Abstract

In this work, we aim to develop cancer cell-targeting AIE dots based on a polyyne-bridged red-emissive AIEgen, 2TPE-4E, through the combination of metabolic engineering and bio-orthogonal reactions. Azide groups on a tumor were efficiently produced by intravenous injection of Ac4ManNAz and glycol-metabolic engineering. These bio-orthogonal azide groups could facilitate the specific targeting of DBCO-AIE dots to the tumor cells undergoing metal-free click reaction in vivo. The efficiency of this targeting strategy could be further improved with the development of new bio-orthogonal chemical groups with higher reactivity and a large amount of AIEgens could be delivered to the tumor for diagnosis.

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  • This paper contributes to the Quantum State Preparation & Representation research area in the Quantum Articles archive.
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  • In this work, we aim to develop cancer cell-targeting AIE dots based on a polyyne-bridged red-emissive AIEgen, 2TPE-4E, through the combination of metabolic engineering and...

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References & Citation Signals

[1] DOI https://doi.org/10.1002/asia.201801609 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/30536637/

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