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Quantum Device Fabrication Process Engineering

Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells.

PubMed
Authors: Lan J, Wu X, Luo L, Liu J, Yang L, Wang F

Year

2019

Paper ID

1543

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

94

Citations

18

Abstract

Anterior gradient protein 2 homolog (AGR) is a potential tumor biomarker and plays an important role in tissue development and regeneration. The intracellular detection of AGR is rarely reported. By conjugating the AGR aptamer with a cytosine base sequence as Ag cluster template, a highly fluorescent probe (MA@AgNCs) was synthesized for targeting intracellular AGR. The MA@AgNCs display a maximum fluorescence peak at 565 nm, and possess an excellent quantum yield QY = 87.43%, small size, great biocompatibility, low toxicity, and good stability. Moreover, the as synthesized MA@AgNCs show high specificity on recognizing breast cancer cells.

Why This Paper Matters

  • This paper contributes to the Quantum Device Fabrication & Process Engineering research area in the Quantum Articles archive.
  • It adds a 2019 reference point for readers tracking recent quantum research.
  • Anterior gradient protein 2 homolog (AGR) is a potential tumor biomarker and plays an important role in tissue development and regeneration.

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References & Citation Signals

[1] DOI https://doi.org/10.1016/j.talanta.2018.12.089 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/30771992/

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