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Long-term multiple color imaging of live cells using quantum dot bioconjugates.

PubMed
Authors: Jaiswal JK, Mattoussi H, Mauro JM, Simon SM

Year

2003

Paper ID

13042

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

109

Citations

0

Abstract

Luminescent quantum dots (QDs)--semiconductor nanocrystals--are a promising alternative to organic dyes for fluorescence-based applications. We have developed procedures for using QDs to label live cells and have demonstrated their use for long-term multicolor imaging of live cells. The two approaches presented are (i) endocytic uptake of QDs and (ii) selective labeling of cell surface proteins with QDs conjugated to antibodies. Live cells labeled using these approaches were used for long-term multicolor imaging. The cells remained stably labeled for over a week as they grew and developed. These approaches should permit the simultaneous study of multiple cells over long periods of time as they proceed through growth and development.

Why This Paper Matters

  • This paper contributes to the Quantum Chemistry research area in the Quantum Articles archive.
  • It adds a 2003 reference point for readers tracking recent quantum research.
  • Luminescent quantum dots (QDs)--semiconductor nanocrystals--are a promising alternative to organic dyes for fluorescence-based applications.

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References & Citation Signals

[1] DOI https://doi.org/10.1038/nbt767 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/12459736/

Local Citation Graph (Related-Paper Links)

Current Paper #13042 #68465 Bounding Eigenstate Overlap fro... #68440 Classical State Preparation for... #68437 Transition-state lattice modes ... #68423 Selective Fermi-Level Pinning: ...

External citation index: OpenAlex citation signal • updated 2026-06-11 01:15:00

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