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Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study.

PubMed
Authors: Abdel-Aziz AA

Year

2007

Paper ID

12689

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

76

Citations

139

Abstract

Versatile method has been developed for synthesis of N-substituted imides. Thus, acid anhydrides, imides and dicarboxylic acids were successfully subjected to dehydrative cyclization with substituted amines using DPPOx and Et(3)N to afford N-substituted imides under mild conditions. The DNA binding and apoptosis induction were investigated with regard to their potential utility as cytotoxic agents. Molecular modeling methods are used to study the cytotoxic activity of the active compounds by means of molecular and quantum mechanics.

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  • This paper contributes to the Quantum Chemistry research area in the Quantum Articles archive.
  • It adds a 2007 reference point for readers tracking recent quantum research.
  • Versatile method has been developed for synthesis of N-substituted imides.

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References & Citation Signals

[1] DOI https://doi.org/10.1016/j.ejmech.2006.12.003 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/17234303/

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