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Quantum Control Electronics System Integration Qubit Coherence Noise Stability Characterization Quantum Chemistry

Biological activity of antitumoural MGBG: the structural variable.

PubMed
Authors: Marques MP, Gil FP, Calheiros R, Battaglia V, Brunati AM, Agostinelli E, Toninello A

Year

2008

Paper ID

12591

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

61

Citations

N/A

Abstract

The present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-L-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG's structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations.

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  • The present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive...

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References & Citation Signals

[1] DOI https://doi.org/10.1007/s00726-007-0009-2 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/18095053/

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