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Quantum dots as donors in fluorescence resonance energy transfer for the bioanalysis of nucleic acids, proteins, and other biological molecules.

PubMed
Authors: Algar WR, Krull UJ

Year

2008

Paper ID

12576

Status

Peer-reviewed

Abstract Read

~2 min

Abstract Words

112

Citations

187

Abstract

Quantum dots (QDs) have a number of unique optical properties that are advantageous in the development of bioanalyses based on fluorescence resonance energy transfer (FRET). Researchers have used QDs as energy donors in FRET schemes for the analysis of nucleic acids, proteins, proteases, haptens, and other small molecules. This paper reviews these applications of QDs. Existing FRET technologies can potentially be improved by using QDs as energy donors instead of conventional fluorophores. Superior brightness, resistance to photobleaching, greater optimization of FRET efficiency, and/or simplified multiplexing are possible with QD donors. The applicability of the Förster formalism to QDs and the feasibility of using QDs as energy acceptors are also reviewed.

Why This Paper Matters

  • This paper contributes to the Quantum Chemistry research area in the Quantum Articles archive.
  • It adds a 2008 reference point for readers tracking recent quantum research.
  • Quantum dots (QDs) have a number of unique optical properties that are advantageous in the development of bioanalyses based on fluorescence resonance energy transfer (FRET).

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References & Citation Signals

[1] DOI https://doi.org/10.1007/s00216-007-1703-3 [2] Publisher https://pubmed.ncbi.nlm.nih.gov/17987281/

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